FA16147
BIO-X

A 769662

Allosteric activator of AMP-activated protein kinase (AMPK) acting on the AMPK-β subunit with therapeutic potential in metabolic disorders such as diabetes, obesity, etc. A769662 also blocks the differentiation of mouse embryonic stem cells (mESCs) and maintains the mESCs in naïve state even in the absence of leukemia inhibitory factor (2i/L).


Technical Data

CAS号: 844499-71-4
别名: A-769662; 6,7-Dihydro-4-hydroxy-3-(2'-hydroxy[1,1'-biphenyl]-4-yl)-6-oxothieno[2,3-b]pyridine-5-carbonitrile; 4-Hydroxy-3-(2'-hydroxy-1,1'-biphenyl-4-yl)-6-oxo-6,7-dihydrothieno[2,3-b]pyridine-5-carbonitrile
产品编码: FA16147
MDL号: MFCD11977269
分子式: C20H12N2O3S
分子量: 360.39

References

参考文献
  • Liu and Yamashita (2019). AMPK activators contribute to maintain naïve pluripotency in mouse embryonic stem cells. Biochemical and Biophysical Research Communications 509(1):24-31.
  • Day et al (2017). AMPK as a Therapeutic Target for Treating Metabolic Diseases. Trends in Endocrinology and Metabolism 28(8):545-560.

Solubility

Stability

Further Information


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