BT162782
BIO-X

TD 114-2 NEW

Potent and selective GSK3-β inhibitor, with IC50 value of 48 nM. Increases Nanog expression and regulates self-renewal in murine embryonic stem cells (ESCs). Induces reprograming of induced pluripotent stem cells (iPSCs) to derive cells from specific lineages.


Technical Data

CAS号: 436866-52-3
别名: 6,​7,​9,​10,​12,​13,​15,​16,​18,​19-Decahydro-5,​29:20,​25-​dimetheno-​26H-​dibenzo[n,​t]​pyrrolo[3,​4-​q]​[1,​4,​7,​10,​13,​22]​tetraoxadiazacyclote​tracosine-​26,​28(27H)​-​dione
产品编码: BT162782
MDL号: MFCD31693845
分子式: C30H31N3O6
分子量: 529.58

References

参考文献
  • Kuo GH et al (2003). Synthesis and discovery of macrocyclic polyoxygenated bis-7-azaindolylmaleimides as a novel series of potent and highly selective glycogen synthase kinase-3beta inhibitors. J Med Chem 46(19):4021-31.
  • Storm MP et al (2007). Regulation of Nanog expression by phosphoinositide 3-kinase-dependent signaling in murine embryonic stem cells. J Biol Chem 282(9):6265-73.
  • Li X et al (2017). Direct Reprogramming of Fibroblasts via a Chemically Induced XEN-like State. Cell Stem Cell 21(2):264-273.

Solubility

Stability

Further Information


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