FM 19G11 NEW

Inhibitor of HIF1-α transcription factor and repressor of HIF1-α-regulated genes in adult and embryonic stem cell models as well as in tumoral cell lines. FM19G11 inhibits the expression of undifferentiating factors Oct4, Sox2, Nanog, and Tgf-α at transcriptional and protein level. FM 19G11 affects also epigenetic events by reducing histone acetylation and leading to repression of p300, a HIF-transcription activation co-factor.

Technical Data

CAS号: 329932-55-0
别名: 2-Oxo-2-(p-tolyl)ethyl 3-(2,4-dinitrobenzamido)benzoate; FM19G11
产品编码: BF168364
分子式: C23H17N3O8
分子量: 463.40


  • El Assar et al (2015). FM19G11 reverses endothelial dysfunction in rat and human arteries through stimulation of the PI3K/Akt/eNOS pathway, independently of mTOR/HIF‐1α activation. British Journal of Pharmacology 172(5):1277-1291.
  • You et al (2018). FM19G11 inhibits O6‐methylguanine DNA‐methyltransferase expression under both hypoxic and normoxic conditions. Cancer Medicine 7(7):3292-3300.
  • Moreno-Manzano et al (2010). FM19G11, a New Hypoxia-inducible Factor (HIF) Modulator, Affects Stem Cell Differentiation Status. Journal of Biological Chemistry 285, 1333-1342.



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