BS162612
BIO-X

SB 334867

A non-peptide antagonist of orexin receptors, selective for subtype OX1 over OX2 (50-fold more). Systemic administration in vivo inhibits orexin-A induced grooming and feeding. Elicits sedative and anorectic effects in vivo. Reduces intake of food in rats, induced by orexin-A or overnight fasting.


Technical Data

CAS号: 792173-99-0
产品编码: BS162612
MDL号: MFCD06411602
分子式: C17H13N5O2
分子量: 319.32

References

参考文献
  • Haynes AC et al (2000). A selective orexin-1 receptor antagonist reduces food consumption in male and female rats. Regul Pept 96(1-2):45-51.
  • Duxon MS et al (2001). Evidence that orexin-A-evoked grooming in the rat is mediated by orexin-1 (OX1) receptors, with downstream 5-HT2C receptor involvement. Psychopharmacology (Berl) 153(2):203-9.
  • Smart D et al (2001). SB-334867-A: the first selective orexin-1 receptor antagonist. Br J Pharmacol 132(6):1179-82.

Solubility

Stability

Further Information


Datasheets

Please Wait...