2-Isobutoxy-1-isobutoxycarbonyl-1,2-dihydroquinoline, also known as IIDQ, is an amide coupling reagent utilised in liquid-phase synthesis. With IIDQ there is no need for the pre-activation step and the efficiency of the coupling is not influenced by the order of the addition of the reagents (amine, carboxylic acid, IIDQ). Furthermore, no guanidinium species are formed with IIDQ, and IIDQ is stable in presence of base. IIDQ is mainly applied in its polymer-supported form, polystyrene-supported IIDQ (PS-IIDQ), which is stable, reactive and efficient. PS-IIDQ requires a simpler purification compared to the free IIDQ and can be easily regenerated. Some applications of PS-IIDQ are in the synthesis of protein conjugates for antibody development and xanthine derivatives to be used as adenosine receptor antagonists.

Technical Data

CAS号: 38428-14-7
别名: IIDQ
产品编码: FI33684
MDL号: MFCD00006702
分子式: C18H25NO3
分子量: 303.40


  • Valeur et al (2005). PS-IIDQ: An Efficient Polymer-Supported Amide Coupling Reagent. Chemical Communications 1164-1166.
  • Sathe et al (2010). Use of Polystyrene-Supported 2-Isobutoxy-1-isobutoxycarbonyl-1,2-dihydro-quinoline for the Preparation of a Hapten–Protein Conjugate for Antibody Development. Bioorganic & Medicinal Chemistry Letters 20:1792-1795.
  • Bandyopadhyay et al (2012). Exploration of Polystyrene-Supported 2-Isobutoxy-1-isobutoxycarbonyl-1,2-dihydroquinoline (PS-IIDQ) as New Coupling Agent for the Synthesis of 8-Substituted Xanthine Derivatives. Tetrahedron Letters 53:4631-4635.



Further Information


Specification: View
MSDS: View
Please Wait...