DNA Cross Linkers

These compounds cause DNA interstrand crosslinks that include natural alkylating agents such as mitomycin C or synthetic agents, such as platinum compounds. These DNA lesions, if left unrepaired, lead to disrupted DNA replication and transcription and therefore have genotoxic and cytotoxic consequences. DNA cross linkers thus have therapeutic applications in treating solid tumors, as well as autoimmune diseases and dermatological conditions. The DNA cross linkers available from Carbosynth are listed below.

产品编码 CAS号 产品名称 描述
BB164239 3543-75-7

Bendamustine hydrochloride

DNA alkylator; purine analog
BC164284 41575-94-4

Carboplatin

Platinum-based anti-cancer agent
BC164289 154-93-8

Carmustine

DNA alkylating agent; antineolplastic
BC164315 15663-27-1

Cisplatin

Platinum-based anti-cancer agent; pro-apoptotic
FE22772 146665-77-2

Eptaplatin

Platinum-based anti-tumor drug
FE37343 2998-57-4

Estramustine

DNA-alkylating agent; anti-cancer agent; estradiol derivative
FI24535 57852-57-0

Idarubicin HCl

Topoisomerase II inhibitor; daunorubicin analog; anti-leukemic; anthracycline
BI166243 3778-73-2

Ifosfamide

Alkylating agent; anti-cancer agent
BL164634 13010-47-4

Lomustine

Alkylating agent; chemotherapeutic agent
FB25047 148-82-3

Melphalan

Nitrogen mustard derivative; DNA crosslinking agent; anti-cancer agent
BM164668 50-07-7

Mitomycin C

Chemoterapeutic agent; DNA crosslinker
FM61451 70476-82-3

Mitoxantrone HCl

Inhibits DNA topoisomerase II; antineoplastic; immunomodulatory; antimicrobial
BN164659 55661-38-6

Nimustine hydrochloride

Antineoplastic; DNA alkylating agent
FP65121 31645-39-3

Palifosfamide

Active metabolite of ifosfamide; alkylates and cross-links DNA; antineoplastic
FP65130 181630-15-9

Picoplatin

Platinum-based anti-cancer agent; induces apoptosis
FP158112 202350-68-3

PNU 159682

DNA alkylating agent; highly potent metabolite of nemorubicin
BP164298 366-70-1

Procarbazine hydrochloride

Anti-cancer alkylating agent; inhibits protein, RNA and DNA synthesis
FS65158 129580-63-8

Satraplatin

Platinum-based chemotherapeutic agent
BT164447 85622-93-1

Temozolomide

DNA methylating agent; anti-tumorigenic; anti-angiogenic
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