Nuclear Receptors

The list of compounds below either mimic or block the activity of endogenous ligands of nuclear receptors.  Broadly, nuclear receptors can be grouped into steroid and non-steroid hormone receptors that are regulated by endogenous agonists. Thirdly, nuclear receptors  with unknown ligand and mode of action are known as orphan receptors. Ligand-bound nuclear receptors undergo conformational changes and act as transcription factors. These bind to DNA response elements in promoters of target genes to regulate transcription. These compounds have therapeutic potential in reproductive, metabolic and proliferative diseases.

产品编码 CAS号 产品名称 描述
BA164136 55079-83-9

Acitretin

Retinoid;activates nuclear retinoid acid receptor; antineoplastic; anti-psoratic BIO-X
BA164138 106685-40-9

Adapalene

Agonist of retinoic acid receptors (RAR-β and RAR-γ); pro-apoptotic BIO-X
FD17242 171746-21-7

AGN 193109

Pan-retinoic acid receptor (RAR) antagonist BIO-X
FA137469 102121-60-8

AM 580

Retinoic acid receptor (RARα) agonist; induces cell differentiation BIO-X
FA64943 956104-40-8

ARN 509

Androgen receptor antagonist; prostate cancer treatment BIO-X
FA103981 1240299-33-5

AZD 3514

Androgen receptor antagonist; has therapeutic application in prostate cancer BIO-X
FA162614 1639042-08-2

AZD 9496

Estrogen receptor (ER) antagonist BIO-X
BZ162710 42422-68-4

Beta-Zearalanol

Estrogen receptor agonist
BZ162711 71030-11-0

Beta-Zearalenol

Estrogen receptor agonist; macrolide
BB164246 153559-49-0

Bexarotene

Retinoid X receptor agonist; antineoplastic BIO-X
BB166159 41859-67-0

Bezafibrate

Peroxisome proliferator-activated receptor agonist; hypolipidemic drug
FB18583 113299-38-0

(S)-Bicalutamide

Androgen receptor antagonist; anti-cancer agent
FB18582 113299-40-4

(R)-Bicalutamide

Androgen receptor antagonist; anti-cancer agent
BB166739 627530-84-1

BMS 564929

Androgen receptor modulator BIO-X
FB167336 573738-99-5

BMS 641988

Androgen receptor (AR) antagonist BIO-X
BB164267 51333-22-3

Budesonide

Glucocorticoid receptor agonist; anti-inflammatory BIO-R
FC09794 32222-06-3

Calcitriol

Agonist of calcitriol receptor; vitamin D3 analog; controls calcium homeostasis BIO-X
FC166171 976-71-6

Canrenone

Mineralocorticoid (aldosterone) receptor antagonist BIO-R
FC19935 302-22-7

Chlormadinone acetate

Progesterone receptor agonist; androgen receptor antagonist; oral contraceptive
FC20428 126544-47-6

Ciclesonide

Glucocorticoid; anti-inflammatory; anti-asthmatic agent BIO-X
BD164311 52214-84-3

Ciprofibrate

Agonist of peroxisome proliferator-activated receptor PPARα ; hypolipidemic BIO-X
FC20501 50-41-9

Clomiphene citrate (cis-trans mixture)

Estrogen receptor modulator; used to treat infertility
FD64992 1110813-31-4

Dacomitinib

Pan-EGFR inhibitor (HER1, HER2 and HER4); antineoplastic BIO-X
FD161413 1297538-32-9

Darolutamide

Androgen receptor antagonist; therapy for endometriosis BIO-X
BD162804 1361504-77-9

DG 172 dihydrochloride

Agonist of peroxisome proliferator-activated receptors PPARβ/δ  BIO-X
FB66440 1428-67-7

DPN

Estrogen ERβ receptor agonist; regulates GluR1, GluR2 and GluR3 expression BIO-X
BD166530 67392-87-4

Drospirenone

Progestogen; anti-androgen; anti-mineralocorticoid BIO-X
BE163306 923978-27-2

Elafibranor

Dual agonist of PPARα and PPARδ receptors BIO-X
FE15969 112093-28-4

Endoxifen

Estrogen receptor antagonist; tamoxifen metabolite; breast cancer therapy
FC65076 915087-33-1

Enzalutamide

Androgen receptor antagonist BIO-X
BE164415 107724-20-9

Eplerenone

Aldosterone blocker BIO-X
FE23206 54350-48-0

Etretinate

Used to treat psoriasis; teratogenic BIO-X
FF23268 65646-68-6

Fenretinide

Modulator of RBP protein; activator of sphingomyelinase; pro-apoptotic BIO-X
FF15770 67-73-2

Fluocinolone acetonide

Corticosteroid; anti-inflammatory; treats dermatological conditions
BF166239 13311-84-7

Flutamide

Non-steroidal androgen receptor antagonist BIO-R
BF161262 80474-14-2

Fluticasone propionate

Glucocorticoid receptor agonist; anti-inflammatory BIO-X
BF160362 80474-14-2

Fluticasone propionate - micronised pharma grade

Glucocorticoid receptor agonist; anti-inflammatory
BF168364 329932-55-0

FM 19G11

Inhibtor of HIF1α transcription factor BIO-X
FT65187 851983-85-2

Galeterone

CYP17 lyase inhibitor; androgen receptor antagonist BIO-X
FG137678 1365888-06-7

GDC 0810

Estrogen receptor degrader; therapeutic use in breast cancer BIO-X
BG166429 1642297-01-5

GDC 0927

Degrader of estrogen receptor BIO-X
BG164505 60282-87-3

Gestodene

Synthetic progestin; contraceptive BIO-X
FG167327 101574-65-6

GSK 4716

Estrogen and related receptor (ERR) agonist BIO-X
FG137681 1346572-63-1

GSK 503

Inhibits EZH2 methyltransferase; antineoplastic BIO-X
FG23723 317318-84-6

GW 0742

Peroxisome proliferator-activated receptor PPARβ/δ agonist BIO-X
FG23720 278779-30-9

GW 4064

Farnesoid X receptor agonist BIO-X
FM23721 317318-70-0

GW 501516

PPAR β/δ agonist; modulates lipid catabolism; anti-obesity agent BIO-X
FC20132 22978-25-2

GW 9662

PPARγ antagonist BIO-X
BH168533 2052128-15-9

H3B 5942

BIO-X
FH23733 1310709-74-0

Halometasone monohydrate

Corticosteroid; anti-inflammatory; treatment for dermatological conditions BIO-X
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