Nuclear Receptors

Compounds in this list act by modulating the interactions among proteins such as chaperone proteins, heat shock proteins, microtubules, transcription factors, immune checkpoint proteins and cytokines. For example, disruption of structural protein interactions such as microtubules have therapeutic applications in cancer treatment. Furthermore, modulating the interaction of bromodomain-containing proteins has implications on chromatin remodelling and epigenetic regulation. Products in this range include small molecule compounds and antibodies.

产品编码 CAS号 产品名称 描述
BA166475 1668553-26-1

A 1210477

Inhibits anti-apoptotic protein MCL1; antineoplastic BIO-X
BA166576 2089148-71-8

A 395

Inhibitor of polycomb protein EED BIO-X
BA166577 1445993-26-9

ABBV 075

Inhibitor of BET bromodomain; antineoplastic BIO-X
BA166477 2138861-99-9

ABBV 744

BET bromodomain inhibitor selective for BDII BIO-X
FA16902 852808-04-9

ABT 737

Inhibitor of Bcl-2, Bcl-xl and Bcl-w pro-survival proteins BIO-X
FI139131 331731-18-1

Adalimumab

Antibody Monoclonal antibody against TNFα; therapy for rheumatoid arthritis
BA165580 862111-32-8

Aflibercept

Recombinant protein against VEGF(A); binds placental growth factor (PIGF)
BA165581 216503-57-0

Alemtuzumab

Antibody Monoclonal antibody against CD52; treatment for multiple sclerosis; anti-cancer
AA17307 75747-14-7

17-Allylaminogeldanamycin

Hsp90 inhibitor; anti-neoplastic antibiotic BIO-X
FC158737 1352066-68-2

AMG 232

Inhibits MDM2-p53 interaction BIO-X
BA172505 2252403-56-6

AMG 510

KRAS G12C inhibitor; racemate of AMG 510
BA172506 2296729-00-3

AMG 510 racemate

Racemic mixture of AMG 510
BA17365 64202-81-9

17-Aminogeldanamycin

Inhibits chaperone protein Hsp90; antineoplastic BIO-X
BA166663 916151-99-0

APTO 253

Induces Kruppel like factor 4 (KLF4), inhibits MYC expression; anti-cancer agent BIO-X
FA159625 289893-27-2

(2S)-Arimoclomol

Regulates expression of chaperonins Hsp70 and Hsp90 
FA30834 289893-25-0

(2R-)Arimoclomol NEW

Regulates expression of chaperonins Hsp70 and Hsp90  BIO-X
FA159626 289893-28-3

(2S)-Arimoclomol maleate

FA159627 289893-26-1

(2R)-Arimoclomol maleate

BIO-X
BA166845 1799328-86-1

ASTX 660

Antagonist of the inhibitor-of-apoptosis-proteins cIAP1/2 and XIAP BIO-X
BA165584 1380723-44-3

Atezolizumab

Antibody Monoclonal antibody against PDL-1; anti-cancer agent
BA171490

Autogramin 2

Autophagy inhibitor that selectively targets the StART domain of GRAMD1A BIO-X
BA165583 1537032-82-8

Avelumab

Antibody Monoclonal antibody against PDL-1; targeted immunotherapy for cancer
FA137649 1124329-14-1

AZ 3146

Monopolar spindle 1 (MPS-1) antagonist BIO-X
FB15804 218600-53-4

Bardoxolone methyl

Activates nuclear factor erythroid 2–related factor 2 (Nrf2)
BB163665 2080306-23-4

BAY 299

Inhibitor of BRPF2 and TAF1 bromodomains BIO-X
BB171473

BI 9321

Nuclear receptor binding SET domain (NSD) 3 antagonist; selectively binds PWWP1 BIO-X
FB139172 130493-03-7

Bimoclomol

Heat shock protein (HSP) co-inducer
BB161276 130641-38-2

Bindarit

Inhibitor of MCP-1 chemokine synthesis; indazolic derivative
FB18841 294891-81-9

BML 286

Inhibits dishevelled (Dvl)-PDZ domain interaction; affects Wnt signaling pathway
BB164045

Brentuximab

Antibody Antibody-drug conjugate targeting CD30; antineoplastic
BB161996 357336-20-0

Brivaracetam

Binds to synaptic vesicle protein SV2A; analog of levetiracetam; anti-epileptic BIO-X
BB170570 1619994-69-2

Bromosporine

Broad spectrum bromodomain inhibitor BIO-X
BB168381 924537-98-4

BT 13 NEW

Inhibitor of RET signalling; GFL mimetic BIO-X
BB170419 924811-53-0

BT 18

Agonist of receptor tyrosine kinase RetA BIO-X
BC165662 1197996-80-7

CBL 0137

Activator of p53; inhibitor of NF-κB BIO-X
BC167790 1177921-72-0

CBR 470-1

Activates NRF2 signalling BIO-X
FC76600 1443437-74-8

CCG 203971

Inhibits MRTF-SRF transcriptional pathway BIO-X
FC64971 620112-78-9

CCG 63802

Inhibits RGS proteins, selective for RGS4 BIO-X
FC64972 620113-73-7

CCG 63808

Reversible inhibitor of RGS proteins BIO-X
BC168608 1693731-40-6

CCT 251236

BIO-X
FC64978 205923-56-4

Cetuximab - Buffer solution

Antibody Monoclonal antibody against EGFR; treatment for colorectal cancer
BC166449

CM 11

Modulator of VHL E3 ubiquitin ligase dimerization
FC20540 209810-38-8

(R/S)-Colchicine

Disrupts tubulin polymerization; destabilizes microtubules; treatment for gout
FC20545 117048-59-6

Combretastatin A4

Tubulin binding agent; targets tumour vasculature
FC20718 4449-51-8

Cyclopamine

Inhibitor of Smoothened receptor and Hedgehog signalling BIO-X
FC20757 83602-39-5

Cyclosporin H

Formyl peptide receptor-1 (FPR-1) antagonist
FC11288 14930-96-2

Cytochalasin B

Blocker of the actin monomers to the actin filament BIO-X
FC29349 22144-77-0

Cytochalasin D

Inhibits actin polymerization BIO-X
BD165586 945721-28-8

Daratumumab - 20mg/ml in water

Antibody Monoclonal antibody against CD38; treatment for multiple myeloma
BD165585 615258-40-7

Denosumab

Antibody Monoclonal antibody against RANKL; anti-resorptive agent for osteoperosis treatment
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