Protein Interactions

Compounds in this list act by modulating the interactions among proteins such as chaperone proteins, heat shock proteins, microtubules, transcription factors, immune checkpoint proteins and cytokines. For example, disruption of structural protein interactions such as microtubules have therapeutic applications in cancer treatment. Furthermore, modulating the interaction of bromodomain-containing proteins has implications on chromatin remodelling and epigenetic regulation. Products in this range include small molecule compounds and antibodies.

产品编码 CAS号 产品名称 描述
FC158737 1352066-68-2

AMG 232

Inhibits MDM2-p53 interaction BIO-X

Anti-human PD-1

Anti-PD-1 mediated immunotherapy currently being explored in cancer treatments
BA178720 1799328-50-9

ASTX660 hydrochloride

BA178721 1799328-90-7

ASTX660 mesylate

BA178722 1799328-88-3

ASTX660 mesylate sulfate

FC76600 1443437-74-8

CCG 203971

Inhibits MRTF-SRF transcriptional pathway BIO-X
FC64971 620112-78-9

CCG 63802

Inhibits RGS proteins, selective for RGS4 BIO-X
FC64972 620113-73-7

CCG 63808

Reversible inhibitor of RGS proteins BIO-X
FC20540 209810-38-8


Disrupts tubulin polymerization; destabilizes microtubules; treatment for gout
FC20545 117048-59-6

Combretastatin A4

Tubulin binding agent; targets tumour vasculature
FC29349 22144-77-0

Cytochalasin D

Inhibits actin polymerization BIO-X
FD110099 934016-19-0

Degarelix acetate

Synthetic peptide used in treatment of prostrate cancer
FE166529 519187-97-4

Edonerpic maleate

Binds to collapsing response mediator protein 2 (CRMP2); neurotrophic agent BIO-X
FE22644 131179-95-8


Haemoglobin (Hb) synthetic allosteric modifier
FE150510 170787-99-2

Efaproxiral sodium

FE104135 858668-07-2

EMD 534085

Inhibits kinesin spindle protein Eg5 BIO-X
FF23511 191930-58-2

Flutax 1

Binds to microtubules BIO-X
FM145129 1539314-06-1

GSK 2881078

Non-steroidal modulator of androgen receptors BIO-X
FG45994 1088965-37-0

GSK 923295

Inhibitor of mitotic kinesin CENP-E BIO-X
FD43075 1300031-49-5

I-BET 151

Isoxazole class pan-BET family inhibitor
FG137683 1260907-17-2

I-BET 762

Inhibitor of BET bromodomain BIO-X
FI24532 780757-88-2

ICG 001

Inhibits interaction between CREB binding protein (CBP) and Wnt/β-catenin BIO-X
FI139130 170277-31-3


Antibody Chimeric monoclonal antibody against TNF-α
FI24737 336113-53-2


Inhibits mitotic kinesin spindle protein (KSP); antineoplastic BIO-X
FE23213 1127442-87-8


Negative control for endo-IWR-1 BIO-X
FD45423 219989-84-1


Microtubule-stabilizing agent; antineoplastic; BIO-X
FI151818 881202-45-5

JNJ 26854165

Activates tumor suppressor p53; anti-proliferative in p53 wild-type tumor cells BIO-X
FJ74795 1268524-69-1

(+/-)-JQ 1

BET bromodomain inhibitor; epigenetic chemical probe
FK167145 309928-48-1

KL 001

Interacts with cytochromes in mammalian circadian clock
FL103735 1005342-46-0

LCL 161

 Second mitochondrial activator of caspase (SMAC) mimetic, IAP inhibitor BIO-X
FM104082 845256-65-7

MK 0731

Kinesin spindle protein (KSP) inhibitor BIO-X
FD145115 935273-79-3

MK 4101

Inhibits Gli1 in hedgehog signalling pathway BIO-X
FP134320 300586-90-7


Activates Oct-4 transcription factor; enhances iPSCs reprogramming BIO-X
FO32672 803712-79-0

Obatoclax mesylate

FO145492 202590-98-5

OTX 015

BET bromodomain inhibitor BIO-X
FP162227 1129540-33-5


Deuterium-labelled internal standard for paclitaxel
FP139135 188039-54-5


FP104240 908115-27-5

PF 04929113

Inhibitor of heat shock protein HSP90 BIO-X
FP104065 1046859-34-0

PF 4942847

Heat shock protein 90 (HSP90) inhibitor; anti-cancer agent BIO-X
FP65141 873436-91-0


Inhibitor of Hsp90 chaperone protein; anti-neoplastic BIO-X
FQ175037 937735-00-7

QM 31

FR159043 947687-13-0


Antibody Monoclonal antibody to VEGFR-2
FR104258 1229705-06-9

RG 7388

Inhibitor of MDM2 E3 ubiquitin-protein ligase and MRP1 transporter BIO-X
FR137715 1044870-39-4

RVX 208

Inhibitor of BET bromodomain BIO-X

SARS-CoV-2 nucleoprotein - from S. cerevisiae, frozen


SARS-CoV-2 Spike glycoprotein trimeric ectodomain - biotinylated - from mammalian CHO cells, frozen


SARS-CoV-2 Spike glycoprotein trimeric ectodomain - biotinylated - from mammalian CHO cells, in glycerol


SARS-CoV-2 Spike glycoprotein trimeric ectodomain - from mammalian CHO cells, frozen


SARS-CoV-2 Spike glycoprotein trimeric ectodomain - from mammalian CHO cells, in glycerol


SARS-CoV-2 Spike glycoprotein trimeric ectodomain - from mammalian HEK293 cells

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