Coupling Agents

Coupling agents are widely used for amide and ester formation, especially for solid-phase peptide synthesis, as they facilitate bond formation without becoming part of the linkage. In synthetic organic chemistry, compounds containing the carbodiimide functionality act as dehydration agents and are often used to activate carboxylic acids towards amide or ester formation. Additives, such as N-hydroxybenzotriazole or N-hydroxysuccinimide, are often added to increase yields and decrease side reactions.


产品编码 CAS号 产品名称 描述
FB01762 56602-33-6


FB15685 164298-25-3


Peptide coupling reagent; does not form volatile or toxic byproducts
FB45526 1433-27-8


Coupling agent for guanylation of amines; used for ketene cyclo-addition
FC02706 530-62-1

N,N'-Carbonyl diimidazole

Coupling agent; also used to make lead sequestering agents and β-enamino acids
FC160903 181517-09-9


Isotopic labelled coupling reagent for mechanistic studies
FC19968 37091-73-9

2-Chloro-1,3-dimethylimidazolinium chloride

Used in synthesis of glycosyl oxazolines and azides; peptide linked to sugars
FC07101 3140-73-6


Peptide coupling agent
FC15427 1075198-30-9

4-{{[(1-Cyano-2-ethoxy-2-oxoethylidene)amino]oxayl] (dimethylamino)methylene]-hexafluorophosphate

A safe coupling agent in phosphonamidation; used in peptides synthesis
FC55888 2491-17-0

N-Cyclohexyl-N'-(2-morpholinoethyl)carbodiimide methyl-p-toluenesulfonate

Water-soluble coupling reagent for peptide synthesis used without base catalysis
FD05508 538-75-0

1,3-Dicyclohexyl carbodiimide

Used in peptide coupling, esterification and invert 2nd alcohol stereochemistry
FD02073 693-13-0

1,3-Diisopropylcarbodiimide 1,3-二异丙基碳二亚胺

Coupling agent for peptides, nucleic acids and asymmetric bis alkyl carbonates
FD02693 1892-57-5


Used in combination with N-hydroxysuccinimide in amide coupling reaction
FD05800 25952-53-8

1-(3-Dimethylaminopropyl)-3-ethylcarbodiimide HCl 1-乙基-(3-二甲基氨基丙基)碳酰二亚胺盐酸盐

Water soluble reagent; carboxyl activating agent; used in immunoconjugates
FD03847 22572-40-3

1-(3-Dimethylaminopropyl)-3-ethylcarbodiimide methiodide

Water soluble crosslinking agent
FD15692 74124-79-1

N,N'-Disuccinimidyl carbonate

FH09243 148893-10-1


Coupling agent with fast reaction rate; catalyses selective acylation
FH07095 94790-37-1

HBTU 苯并三氮唑-N,N,N',N'-四甲基脲六氟磷酸盐

High yielding for peptide synthesis; suitable in both solid and solution phase
FH15560 330645-87-9


Stable coupling agent for hindered substrates; faster reaction rate than HBTU
FP15550 128625-52-5


FT07096 125700-67-6


Versatile agent in solid-phase peptide synthesis with low degree of racemisation
FT35332 164298-23-1


Coupling agent for peptide synthesis; non-hygroscopic air stable salt
FT15567 136849-72-4


FT15580 105832-38-0


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