These compounds cause DNA interstrand crosslinks that include natural alkylating agents such as mitomycin C or synthetic agents, such as platinum compounds. These DNA lesions, if left unrepaired, lead to disrupted DNA replication and transcription and therefore have genotoxic and cytotoxic consequences. DNA cross linkers thus have therapeutic applications in treating solid tumors, as well as autoimmune diseases and dermatological conditions. The DNA cross linkers available from Carbosynth are listed below.

产品编码 CAS号 产品名称 描述
BB164239 3543-75-7

Bendamustine hydrochloride

DNA alkylator; purine analog
BC164284 41575-94-4


Platinum-based anti-cancer agent
BC164289 154-93-8

Carmustine- Bio-X

DNA alkylating agent; antineolplastic
BC164315 15663-27-1


Platinum-based anti-cancer agent; pro-apoptotic
FE22772 146665-77-2


Platinum-based anti-tumor drug
FE37343 2998-57-4


DNA-alkylating agent; anti-cancer agent; estradiol derivative
FI24535 57852-57-0

Idarubicin hydrochloride

Topoisomerase II inhibitor; daunorubicin analog; anti-leukemic; anthracycline
BI166243 3778-73-2

Ifosfamide - Bio-X

Alkylating agent; anti-cancer agent
BL164634 13010-47-4

Lomustine- Bio-X

Alkylating agent; chemotherapeutic agent
FB25047 148-82-3


Nitrogen mustard derivative; DNA crosslinking agent; anti-cancer agent
FM61588 3223-07-2

Melphalan hydrochloride

Nitrogen mustard derivative; DNA crosslinking agent; anti-cancer agent
BM164668 50-07-7

Mitomycin C- Bio-X

Chemoterapeutic agent; DNA crosslinker
FM61451 70476-82-3

Mitoxantrone hydrochloride

Inhibits DNA topoisomerase II; antineoplastic; immunomodulatory; antimicrobial
BN164659 55661-38-6

Nimustine hydrochloride

Antineoplastic; DNA alkylating agent
FP65121 31645-39-3


Active metabolite of ifosfamide; alkylates and cross-links DNA; antineoplastic
FP65130 181630-15-9


Platinum-based anti-cancer agent; induces apoptosis
FP158112 202350-68-3

PNU 159682

DNA alkylating agent; highly potent metabolite of nemorubicin
BP164298 366-70-1

Procarbazine hydrochloride

Anti-cancer alkylating agent; inhibits protein, RNA and DNA synthesis
FR55382 58994-96-0


Anti-cancer; inhibits proliferation of cancer cells by DNA cross-linking
FS65158 129580-63-8


Platinum-based chemotherapeutic agent
BT164447 85622-93-1

Temozolomide- Bio-X

DNA methylating agent; anti-tumorigenic; anti-angiogenic
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