DNA交联剂
These compounds cause DNA interstrand crosslinks that include natural alkylating agents such as mitomycin C or synthetic agents, such as platinum compounds. These DNA lesions, if left unrepaired, lead to disrupted DNA replication and transcription and therefore have genotoxic and cytotoxic consequences. DNA cross linkers thus have therapeutic applications in treating solid tumors, as well as autoimmune diseases and dermatological conditions. The DNA cross linkers available from Carbosynth are listed below.
| 产品编码 |
CAS号 |
产品名称 |
|
描述 |
|
| BB164239 |
3543-75-7 |
Bendamustine hydrochloride |
|
DNA alkylator; purine analog |
|
| BC164284 |
41575-94-4 |
Carboplatin |
|
Platinum-based anti-cancer agent |
|
| BC164289 |
154-93-8 |
Carmustine- Bio-X |
|
DNA alkylating agent; antineolplastic |
|
| BC164315 |
15663-27-1 |
Cisplatin |
|
Platinum-based anti-cancer agent; pro-apoptotic |
|
| FE22772 |
146665-77-2 |
Eptaplatin |
|
Platinum-based anti-tumor drug |
|
| FE37343 |
2998-57-4 |
Estramustine |
|
DNA-alkylating agent; anti-cancer agent; estradiol derivative |
|
| FI24535 |
57852-57-0 |
Idarubicin hydrochloride |
|
Topoisomerase II inhibitor; daunorubicin analog; anti-leukemic; anthracycline |
|
| BI166243 |
3778-73-2 |
Ifosfamide |
|
Alkylating agent; anti-cancer agent |
|
| BL164634 |
13010-47-4 |
Lomustine- Bio-X |
|
Alkylating agent; chemotherapeutic agent |
|
| FB25047 |
148-82-3 |
Melphalan |
|
Nitrogen mustard derivative; DNA crosslinking agent; anti-cancer agent |
|
| FM61588 |
3223-07-2 |
Melphalan hydrochloride |
|
Nitrogen mustard derivative; DNA crosslinking agent; anti-cancer agent |
|
| BM164668 |
50-07-7 |
Mitomycin C- Bio-X |
|
Chemoterapeutic agent; DNA crosslinker |
|
| FM61451 |
70476-82-3 |
Mitoxantrone hydrochloride |
|
Inhibits DNA topoisomerase II; antineoplastic; immunomodulatory; antimicrobial |
|
| BN164659 |
55661-38-6 |
Nimustine hydrochloride |
|
Antineoplastic; DNA alkylating agent |
|
| FP65121 |
31645-39-3 |
Palifosfamide |
|
Active metabolite of ifosfamide; alkylates and cross-links DNA; antineoplastic |
|
| FP65130 |
181630-15-9 |
Picoplatin |
|
Platinum-based anti-cancer agent; induces apoptosis |
|
| FP158112 |
202350-68-3 |
PNU 159682 |
|
DNA alkylating agent; highly potent metabolite of nemorubicin |
|
| BP164298 |
366-70-1 |
Procarbazine hydrochloride |
|
Anti-cancer alkylating agent; inhibits protein, RNA and DNA synthesis |
|
| FR55382 |
58994-96-0 |
Ranimustine |
|
Anti-cancer; inhibits proliferation of cancer cells by DNA cross-linking |
|
| FS65158 |
129580-63-8 |
Satraplatin |
|
Platinum-based chemotherapeutic agent |
|
| BT164447 |
85622-93-1 |
Temozolomide- Bio-X |
|
DNA methylating agent; anti-tumorigenic; anti-angiogenic |
|