核受体

The list of compounds below either mimic or block the activity of endogenous ligands of nuclear receptors.  Broadly, nuclear receptors can be grouped into steroid and non-steroid hormone receptors that are regulated by endogenous agonists. Thirdly, nuclear receptors  with unknown ligand and mode of action are known as orphan receptors. Ligand-bound nuclear receptors undergo conformational changes and act as transcription factors. These bind to DNA response elements in promoters of target genes to regulate transcription. These compounds have therapeutic potential in reproductive, metabolic and proliferative diseases.