核受体

The list of compounds below either mimic or block the activity of endogenous ligands of nuclear receptors.  Broadly, nuclear receptors can be grouped into steroid and non-steroid hormone receptors that are regulated by endogenous agonists. Thirdly, nuclear receptors  with unknown ligand and mode of action are known as orphan receptors. Ligand-bound nuclear receptors undergo conformational changes and act as transcription factors. These bind to DNA response elements in promoters of target genes to regulate transcription. These compounds have therapeutic potential in reproductive, metabolic and proliferative diseases.

产品编码 CAS号 产品名称 描述
FC09794 32222-06-3

1a,25-Dihydroxyvitamin D3

Agonist of calcitriol receptor; vitamin D3 analog; controls calcium homeostasis
FM162210 213250-70-5

2MD

Agonist of vitamin D receptor in bone
FR11993 08.03.5300

9-cis-Retinoic acid

Ligand of retinoid X receptor RXRα
BA164136 55079-83-9

Acitretin- Bio-X

Retinoid;activates nuclear retinoid acid receptor; antineoplastic; anti-psoratic
BA164138 106685-40-9

Adapalene- Bio-X

Agonist of retinoic acid receptors (RAR-β and RAR-γ); pro-apoptotic
FD17242 171746-21-7

AGN 193109

Pan-retinoic acid receptor (RAR) antagonist
FA137469 102121-60-8

AM 580

Retinoic acid receptor (RARα) agonist; induces cell differentiation
FA64943 956104-40-8

ARN 509

Androgen receptor antagonist; prostate cancer treatment
FA103981 1240299-33-5

AZD 3514

Androgen receptor antagonist; has therapeutic application in prostate cancer
FA162614 1639042-08-2

AZD 9496

Estrogen receptor (ER) antagonist
BZ162710 42422-68-4

Beta-Zearalanol

Estrogen receptor agonist
BZ162711 71030-11-0

Beta-Zearalenol

Estrogen receptor agonist; macrolide
BB164246 153559-49-0

Bexarotene- Bio-X

Agonist of retinoid X receptor; neuroprotective
BB166159 41859-67-0

Bezafibrate

Peroxisome proliferator-activated receptor agonist; hypolipidemic drug
BB166739 627530-84-1

BMS 564929

Androgen receptor modulator
FB167336 573738-99-5

BMS 641988

Androgen receptor (AR) antagonist
BB164267 51333-22-3

Budesonide

Glucocorticoid receptor agonist; anti-inflammatory BIO-R
FC166171 976-71-6

Canrenone

Mineralocorticoid (aldosterone) receptor antagonist BIO-R
BC170775 1178240-51-1

CCG 58150

Rho/MRTF/SRF mediated gene transcription inhibitor
FC19935 302-22-7

Chlormadinone acetate

Progesterone receptor agonist; androgen receptor antagonist; oral contraceptive
FC20428 126544-47-6

Ciclesonide

Glucocorticoid; anti-inflammatory; anti-asthmatic agent
BD164311 52214-84-3

Ciprofibrate- Bio-X

Agonist of peroxisome proliferator-activated receptor PPARα ; hypolipidemic
FC20501 50-41-9

Clomiphene citrate (cis-trans mixture)

Estrogen receptor modulator; used to treat infertility
FD64992 1110813-31-4

Dacomitinib

Pan-EGFR inhibitor (HER1, HER2 and HER4); antineoplastic
FD161413 1297538-32-9

Darolutamide

Androgen receptor antagonist; therapy for endometriosis
BD162804 1361504-77-9

DG 172 hydrochloride

Agonist of peroxisome proliferator-activated receptors PPARβ/δ 
FB66440 1428-67-7

DPN

Estrogen ERβ receptor agonist; regulates GluR1, GluR2 and GluR3 expression
BD166530 67392-87-4

Drospirenone- Bio-X

Progestogen; anti-androgen; anti-mineralocorticoid
FE177759 1349723-93-8

Elacestrant dihydrochloride

BE163306 923978-27-2

Elafibranor

Dual agonist of PPARα and PPARδ receptors
FC65076 915087-33-1

Enzalutamide

Androgen receptor antagonist
BE164415 107724-20-9

Eplerenone- Bio-X

Aldosterone blocker
FE23206 54350-48-0

Etretinate

Used to treat psoriasis; teratogenic
FF23268 65646-68-6

Fenretinide

Modulator of RBP protein; activator of sphingomyelinase; pro-apoptotic
FF15770 67-73-2

Fluocinolone acetonide

Corticosteroid; anti-inflammatory; treats dermatological conditions
BF176452 67-73-2

Fluocinolone acetonide - BP

BF166239 13311-84-7

Flutamide

Non-steroidal androgen receptor antagonist BIO-R
BF161262 80474-14-2

Fluticasone propionate- Bio-X

Glucocorticoid receptor agonist; anti-inflammatory
BF160362 80474-14-2

Fluticasone propionate - micronised pharma grade

Glucocorticoid receptor agonist; anti-inflammatory
BF168364 329932-55-0

FM 19G11 NEW

Inhibitor of HIF1α transcription factor
FT65187 851983-85-2

Galeterone

CYP17 lyase inhibitor; androgen receptor antagonist
FG137678 1365888-06-7

GDC 0810

Estrogen receptor degrader; therapeutic use in breast cancer
BG166429 1642297-01-5

GDC 0927

Degrader of estrogen receptor
BG164505 60282-87-3

Gestodene- Bio-X

Synthetic progestin; contraceptive
FG167327 101574-65-6

GSK 4716

Agonist of estrogen-related receptors ERRβ and ERRγ
FG137681 1346572-63-1

GSK 503

Inhibits EZH2 methyltransferase; antineoplastic
FG23723 317318-84-6

GW 0742

Peroxisome proliferator-activated receptor PPARβ/δ agonist
FG23720 278779-30-9

GW 4064

Farnesoid X receptor agonist
FM23721 317318-70-0

GW 501516

PPAR β/δ agonist; modulates lipid catabolism; anti-obesity agent
FC20132 22978-25-2

GW 9662

PPARγ antagonist
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