蛋白质相互作用

Compounds in this list act by modulating the interactions among proteins such as chaperone proteins, heat shock proteins, microtubules, transcription factors, immune checkpoint proteins and cytokines. For example, disruption of structural protein interactions such as microtubules have therapeutic applications in cancer treatment. Furthermore, modulating the interaction of bromodomain-containing proteins has implications on chromatin remodelling and epigenetic regulation. Products in this range include small molecule compounds and antibodies.

产品编码 CAS号 产品名称 描述
AA17307 75747-14-7

17-Allylaminogeldanamycin

Hsp90 inhibitor; anti-neoplastic antibiotic
BA17365 64202-81-9

17-Aminogeldanamycin

Inhibits chaperone protein Hsp90; antineoplastic
AD34908 467214-21-7

17-DMAG hydrochloride

Heat shock protein 90 (HSP90) inhibitor
BA166475 1668553-26-1

A 1210477

Inhibits anti-apoptotic protein MCL1; antineoplastic
BA166576 2089148-71-8

A 395

Inhibitor of polycomb protein EED
BA166577 1445993-26-9

ABBV 075

Inhibitor of BET bromodomain; antineoplastic
BA166477 2138861-99-9

ABBV 744

BET bromodomain inhibitor selective for BDII
FA16902 852808-04-9

ABT 737

Inhibitor of Bcl-2, Bcl-xl and Bcl-w pro-survival proteins
FI139131 331731-18-1

Adalimumab

Antibody Monoclonal antibody against TNFα; therapy for rheumatoid arthritis
BA165580 862111-32-8

Aflibercept - approx 40mg/ml solution

Recombinant protein against VEGF(A); binds placental growth factor (PIGF)
BA165581 216503-57-0

Alemtuzumab

Antibody Monoclonal antibody against CD52; treatment for multiple sclerosis; anti-cancer
FC158737 1352066-68-2

AMG 232

Inhibits MDM2-p53 interaction
BA172505 2252403-56-6

AMG 510

KRAS G12C inhibitor
BA172506 2296729-00-3

AMG 510 racemate

Racemic mixture of AMG 510
BA176793

Anti-human PD-1

Anti-PD-1 mediated immunotherapy currently being explored in cancer treatments
BA166663 916151-99-0

APTO 253

Induces Kruppel like factor 4 (KLF4), inhibits MYC expression; anti-cancer agent
BA166845 1799328-86-1

ASTX 660

Antagonist of the inhibitor-of-apoptosis-proteins cIAP1/2 and XIAP
BA165584 1380723-44-3

Atezolizumab

Antibody Monoclonal antibody against PDL-1; anti-cancer agent
BA171490

Autogramin 2

Autophagy inhibitor that selectively targets the StART domain of GRAMD1A
BA165583 1537032-82-8

Avelumab

Antibody Monoclonal antibody against PDL-1; targeted immunotherapy for cancer
FA137649 1124329-14-1

AZ 3146

Monopolar spindle 1 (MPS-1) antagonist
FB15804 218600-53-4

Bardoxolone methyl

Activates nuclear factor erythroid 2–related factor 2 (Nrf2)
BB163665 2080306-23-4

BAY 299

Inhibitor of BRPF2 and TAF1 bromodomains
BB171473

BI 9321

Nuclear receptor binding SET domain (NSD) 3 antagonist; selectively binds PWWP1
FB139172 130493-03-7

Bimoclomol

Heat shock protein (HSP) co-inducer
BB161276 130641-38-2

Bindarit

Inhibitor of MCP-1 chemokine synthesis; indazolic derivative
FB175707 1391108-10-3

BM 1074

Potent Bcl-2/Bcl-xL inhibitor
FB18841 294891-81-9

BML 286

Inhibits dishevelled (Dvl)-PDZ domain interaction; affects Wnt signaling pathway
BB164045

Brentuximab

Antibody Antibody-drug conjugate targeting CD30; antineoplastic
BB170570 1619994-69-2

Bromosporine

Broad spectrum bromodomain inhibitor
BB168381 924537-98-4

BT 13 NEW

Inhibitor of RET signalling; GFL mimetic
BB170419 924811-53-0

BT 18

Agonist of receptor tyrosine kinase RetA
BC165662 1197996-80-7

CBL 0137

Activator of p53; inhibitor of NF-κB
BC167790 1177921-72-0

CBR 470-1

Activates NRF2 signalling
FC76600 1443437-74-8

CCG 203971

Inhibits MRTF-SRF transcriptional pathway
FC64971 620112-78-9

CCG 63802

Inhibits RGS proteins, selective for RGS4
FC64972 620113-73-7

CCG 63808

Reversible inhibitor of RGS proteins
BC168608 1693731-40-6

CCT 251236

FC64978 205923-56-4

Cetuximab - Buffer solution

Antibody Monoclonal antibody against EGFR; treatment for colorectal cancer
BC166449

CM 11

Modulator of VHL E3 ubiquitin ligase dimerization
FC20545 117048-59-6

Combretastatin A4

Tubulin binding agent; targets tumour vasculature
FC20718 4449-51-8

Cyclopamine

Inhibitor of Smoothened receptor and Hedgehog signalling
FC20757 83602-39-5

Cyclosporin H

Formyl peptide receptor-1 (FPR-1) antagonist
FC11288 14930-96-2

Cytochalasin B

Blocker of the actin monomers to the actin filament
FC29349 22144-77-0

Cytochalasin D

Inhibits actin polymerization
BD165586 945721-28-8

Daratumumab - 20mg/ml in water

Antibody Monoclonal antibody against CD38; treatment for multiple myeloma
FD110099 934016-19-0

Degarelix acetate

Synthetic peptide used in treatment of prostrate cancer
BD165585 615258-40-7

Denosumab

Antibody Monoclonal antibody against RANKL; anti-resorptive agent for osteoperosis treatment
BD164046 1363687-32-4

Dinutuximab

Antibody Anti-GD2 monoclonal antibody
BD164373 114977-28-5

Docetaxel- Bio-X

Stabilizes tubulin; anti-cancer agent
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